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New information is rapidly accumulating about the genetic subgroups that lead to fibroid formation, which might aid further understanding of the clinical heterogeneity of this disease and lead to individualized treatments

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CGRP released from cutaneous trigeminal nerve fibers and acts on surrounding Schwann cells, perpetuating cutaneous allodynia through a cyclic AMP-dependent mechanism that generates NO in endosomes (31)

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[19,20] Therefore, some recent evidence recommends individualized planning for patient treatment